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Journals
Cancers
Volume 16
Issue 13
10.3390/cancers16132414
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Open AccessArticle
by Zsolt Abonyi-Tóth SciProfiles Scilit Preprints.org Google Scholar György Rokszin SciProfiles Scilit Preprints.org Google Scholar Gábor Sütő SciProfiles Scilit Preprints.org Google Scholar Ibolya Fábián SciProfiles Scilit Preprints.org Google Scholar Zoltán Kiss SciProfiles Scilit Preprints.org Google Scholar György Jermendy SciProfiles Scilit Preprints.org Google Scholar Péter Kempler SciProfiles Scilit Preprints.org Google Scholar Csaba Lengyel SciProfiles Scilit Preprints.org Google Scholar István Wittmann SciProfiles Scilit Preprints.org Google Scholar Gergő A. Molnár SciProfiles Scilit Preprints.org Google Scholar 
Zsolt Abonyi-Tóth
, György Rokszin, Gábor SütőIbolya FábiánZoltán KissGyörgy Jermendy, Péter KemplerCsaba LengyelIstván Wittmann and Gergő A. Molnár
1
RxTarget Ltd., 5000 Szolnok, Hungary
2
Department of Biostatistics, University of Veterinary Medicine, 1078 Budapest, Hungary
3
Second Department of Medicine and Nephrology-Diabetes Centre, University of Pécs Medical School, 7624 Pécs, Hungary
4
Department of Internal Medicine, Bajcsy-Zsilinszky Hospital, 1106 Budapest, Hungary
5
Department of Medicine and Oncology, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary
6
Department of Internal Medicine, University of Szeged, 6720 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Cancers 2024, 16(13), 2414; https://doi.org/10.3390/cancers16132414 (registeringDOI)
Submission received: 17 May 2024 / Revised: 27 June 2024 / Accepted: 28 June 2024 / Published: 29 June 2024
(This article belongs to the Section Cancer Epidemiology and Prevention)
Simple Summary
This study aimed to determine the risk and rate of development of overall and site-specific cancer in patients with type 2 diabetes mellitus compared with non-diabetic individuals. In this retrospective cohort study, excess incidence of cancer was found in patients with type 2 diabetes mellitus. While the incidence of cancer decreased in non-diabetic controls between 2015 and 2019 in most age groups and for several cancer sites, this decrease was less significant among patients with type 2 diabetes mellitus. Therefore, the results of this study demonstrate that the presence of type 2 diabetes mellitus leads to a higher incidence of cancer.
Abstract
(1) Background: Among the chronic complications of type 2 diabetes mellitus, cancer has become the leading cause of death in several countries. Our objective was to determine whether prevalent type 2 diabetes mellitus is associated with a higher incidence of cancer. (2) Methods: This study comprised a nationwide analysis conducted in Hungary. The study population was divided into two groups: a type 2 diabetes mellitus group vs. a non-diabetic group. The primary outcome was the risk related to overall cancer incidence; a key secondary outcome was the overall incidence of cancer in distinct study years; and a further outcome was the annual percent changes. (3) Results: The odds ratio related to the overall incidence of cancer was 2.50 (95% confidence interval: 2.46–2.55, p < 0.0001) in patients with diabetes as related to non-diabetic controls. The odds ratio was higher in males than in females [ORmales: 2.76 (2.70–2.82) vs. ORfemales: 2.27 (2.22–2.33), p < 0.05 for male-to-female comparison]. The annual cancer incidence rate declined in non-diabetic controls, but not in patients with diabetes [−1.79% (−2.07–−1.52%), p < 0.0001] vs. −0.50% (−1.12–+0.10%), p = 0.0991]. Several types of cancer showed a decreasing tendency in non-diabetic controls, but not in patients with type 2 diabetes. (4) Conclusions: Type 2 diabetes is associated with a higher risk of cancer. While the cancer incidence decreased for non-diabetic individuals with time, it remained unchanged in patients with T2DM.
Keywords: diabetes mellitus (type 2); cancer; incidence; age; epidemiology
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MDPI and ACS Style
Abonyi-Tóth, Z.; Rokszin, G.; Sütő, G.; Fábián, I.; Kiss, Z.; Jermendy, G.; Kempler, P.; Lengyel, C.; Wittmann, I.; Molnár, G.A. Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Cancers 2024, 16, 2414. https://doi.org/10.3390/cancers16132414
AMA Style
Abonyi-Tóth Z, Rokszin G, Sütő G, Fábián I, Kiss Z, Jermendy G, Kempler P, Lengyel C, Wittmann I, Molnár GA. Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Cancers. 2024; 16(13):2414. https://doi.org/10.3390/cancers16132414
Chicago/Turabian Style
Abonyi-Tóth, Zsolt, György Rokszin, Gábor Sütő, Ibolya Fábián, Zoltán Kiss, György Jermendy, Péter Kempler, Csaba Lengyel, István Wittmann, and Gergő A. Molnár. 2024. "Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2)" Cancers 16, no. 13: 2414. https://doi.org/10.3390/cancers16132414
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
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MDPI and ACS Style
Abonyi-Tóth, Z.; Rokszin, G.; Sütő, G.; Fábián, I.; Kiss, Z.; Jermendy, G.; Kempler, P.; Lengyel, C.; Wittmann, I.; Molnár, G.A. Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Cancers 2024, 16, 2414. https://doi.org/10.3390/cancers16132414
AMA Style
Abonyi-Tóth Z, Rokszin G, Sütő G, Fábián I, Kiss Z, Jermendy G, Kempler P, Lengyel C, Wittmann I, Molnár GA. Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2). Cancers. 2024; 16(13):2414. https://doi.org/10.3390/cancers16132414
Chicago/Turabian Style
Abonyi-Tóth, Zsolt, György Rokszin, Gábor Sütő, Ibolya Fábián, Zoltán Kiss, György Jermendy, Péter Kempler, Csaba Lengyel, István Wittmann, and Gergő A. Molnár. 2024. "Incident Cancer Risk of Patients with Prevalent Type 2 Diabetes Mellitus in Hungary (Part 2)" Cancers 16, no. 13: 2414. https://doi.org/10.3390/cancers16132414
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.
